- Title
- Redefinition of Fatty Liver Disease from NAFLD to MAFLD through the Lens of Drug Development and Regulatory Science
- Creator
- Fouad, Yasser; Palmer, Melissa; Landgren, Henrik; Karsdal, Morten A.; Blake, Martin; Shapiro, David A.; Gruss, Hans-Juergen; Sheikh, Muhammad Y.; Attia, Dina; Bollipo, Steven; Smith, Alastair D.; Freilich, Bradley; Chen, Minjun; Gish, RG; Schuppan, D; Regev, Arie; Banerjee, Rajarshi; Myers, Rob; Riccio, Robert; Torstenson, Richard; Younes, Ramy; Arora, Puneet S.
- Relation
- Journal of Clinical and Translational Hepatology Vol. 10, Issue 2, p. 374-382
- Publisher Link
- http://dx.doi.org/10.14218/JCTH.2021.00408
- Publisher
- Xia & He Publishing
- Resource Type
- journal article
- Date
- 2022
- Description
- Metabolic (dysfunction)-associated fatty liver disease (MAFLD) affects a third of the population and is a leading cause of liver-related death. Since no effective treatments exist, novel approaches to drug development are required. Unfortunately, outdated terminology and definitions of the disease are hampering efforts to develop new drugs and treatments. An international consensus panel has put forth an influential proposal for the disease to be renamed from nonalcoholic fatty liver disease (NAFLD) to MAFLD, including a proposal for how the disease should be diagnosed. As allies with the many stakeholders in MAFLD care―including patients, patients’ advocates, clinicians, researchers, nurse and allied health groups, regional societies, and others―we are aware of the negative consequences of the NAFLD term and definition. We share the sense of urgency for change and will act in new ways to achieve our goals. Although there is much work to be done to overcome clinical inertia and reverse worrisome recent trends, the MAFLD initiative provides a firm foundation to build on. It provides a roadmap for moving forward toward more efficient care and affordable, sustainable drug and device innovation in MAFLD care. We hope it will bring promising new opportunities for a brighter future for MAFLD care and improve care and outcomes for patients of one of the globe’s largest and costliest public health burdens. From this viewpoint, we have revisited this initiative through the perspectives of drug development and regulatory science.
- Subject
- NAFLD; MAFLD; NASH; fatty liver disease; liver; fibrosis
- Identifier
- http://hdl.handle.net/1959.13/1462550
- Identifier
- uon:46497
- Identifier
- ISSN:2225-0719
- Rights
- © 2022 The Author(s). This article has been published under the terms of Creative Commons Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0), which permits noncommercial unrestricted use, distribution, and reproduction in any medium, provided that the following statement is provided. “This article has been published in Journal of Clinical and Translational Hepatology at https://doi.org/10.14218/JCTH.2021.00408 and can also be viewed on the Journal’s website at http://www.jcthnet.com.
- Language
- eng
- Full Text
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